Title

Adrenergic Regulation of Protein Synthesis in Rat Submandibular Salivary Gland Cells

Document Type

Article

Publication Date

1984

Journal Title

Archives of Oral Biology

ISSN

0003-9969

Volume

29

Issue

7

First Page

499

Last Page

502

DOI

http://dx.doi.org/10.1016/0003-9969(84)90069-4

Abstract

Epinephrine, a mixed α- and β-adrenergic agonist, modulated new protein synthesis in dispersed rat submandibular cells. Both adrenoreceptors separately could increase protein synthesis after cells were exposed to [14C]-leucine for 10 min and then with 1 mM unlabelled leucine for 10–30 min. The extent of response was dependent on the concentration of epinephrine to which cells were exposed. Alteration in the sequence of exposure of cells to tracer and agonist changed the direction of agonist response.

Keywords

Adrenergic, epinephrine, rats, submandibular gland, leucine, salivary proteins

PubMed ID

6591881