Title

Rat Parotid Cell Function in Vitro Following X Irradiation in Vivo

Document Type

Article

Publication Date

2-1984

Journal Title

Radiation Research

ISSN

0033-7587

Volume

97

Issue

2

First Page

386

Last Page

395

DOI

http://dx.doi.org/10.2307/3576289

Abstract

The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K+ efflux and reuptake), amino acid transport (alpha-amino[14C]isobutyric acid), and an intermediary metabolic response ( [14C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.

Keywords

Parotid gland, rats, amino acids, amylases, glucose, protein, irradiation, saliva secretion

PubMed ID

6198673