Engineering and Computer Science Faculty Presentations

Title

Low Dose Nicotine Exposure Improves Posterior Spinal Fusion in an In Vivo Rabbit Model

Document Type

Conference Presentation

Conference/Event

24th North American Spine Society (NASS) Annual Meeting

Location

San Fancisco, CA

Event Date

11-10-2009

Abstract

BACKGROUND CONTEXT: A previous pilot study by our group demonstrated that nicotine administration via transdermal nicotine patch showed consistent serum nicotine levels whereas administration via the more commonly utilized mini-osmotic pump resulted in large variations in serum levels of nicotine of rabbits. In other work, we have previously demonstrated that nicotine delivered via a transdermal patch enhanced posterior spinal fusion rates in rabbits. This is contrary to studies published by other groups where nicotine administration decreased fusion rates.

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