Engineering and Computer Science Faculty Publications

Title

Low Dose Nicotine Exposure Improves Posterior Spinal Fusion in an In Vivo Rabbit Model

Document Type

Conference Proceeding

Publication Date

10-2009

Journal Title

The Spine Journal

Volume

9

Issue

10

First Page

12S

DOI

http://dx.doi.org/10.1016/j.spinee.2009.08.029

Abstract

BACKGROUND CONTEXT: A previous pilot study by our group demonstrated that nicotine administration via transdermal nicotine patch showed consistent serum nicotine levels whereas administration via the more commonly utilized mini-osmotic pump resulted in large variations in serum levels of nicotine of rabbits. In other work, we have previously demonstrated that nicotine delivered via a transdermal patch enhanced posterior spinal fusion rates in rabbits. This is contrary to studies published by other groups where nicotine administration decreased fusion rates.