Low Dose Nicotine Exposure Improves Posterior Spinal Fusion in an In Vivo Rabbit Model
The Spine Journal
BACKGROUND CONTEXT: A previous pilot study by our group demonstrated that nicotine administration via transdermal nicotine patch showed consistent serum nicotine levels whereas administration via the more commonly utilized mini-osmotic pump resulted in large variations in serum levels of nicotine of rabbits. In other work, we have previously demonstrated that nicotine delivered via a transdermal patch enhanced posterior spinal fusion rates in rabbits. This is contrary to studies published by other groups where nicotine administration decreased fusion rates.
France, John C.; Daffner, Scott D.; Smalley, Chad; Waugh, Stacey; Norman, Timothy L.; Clovis, Nina; Smith, Suzanne; Kish, Vincent; and Mukherjee, Nilay, "Low Dose Nicotine Exposure Improves Posterior Spinal Fusion in an In Vivo Rabbit Model" (2009). Engineering and Computer Science Faculty Publications. 245.