Engineering and Computer Science Faculty Publications

Title

Nicotine Increases Osteoblast Activity in In Vitro Cell Culture in a Dose Dependent Manner

Document Type

Conference Proceeding

Publication Date

10-2009

Journal Title

The Spine Journal

Volume

9

Issue

10

First Page

28S

DOI

http://dx.doi.org/10.1016/j.spinee.2009.08.066

Abstract

BACKGROUND CONTEXT: Prior studies by our group have shown that nicotine delivered via a transdermal nicotine patch significantly enhanced posterior spinal fusion rates in rabbits. This runs contrary to previously published studies by other groups in which nicotine administration decreased fusion rates. Hence, there may be a dose-dependent effect of nicotine on posterior spinal fusion outcomes.