Pharmaceutical Sciences Faculty Publications

Title

Central Inhibitory Activity of the Aqueous Extract of Crinum giganteum

Document Type

Article

Publication Date

2-2003

Journal Title

Fitoterapia

ISSN

0367-326X

Volume

74

Issue

1-2

First Page

23

Last Page

28

DOI

http://dx.doi.org/10.1016/s0367-326x(02)00287-3

PubMed ID

12628390

Abstract

The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD50 in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity.

Keywords

Crinum giganteum, spontaneous motor activity, pentobarbital sleeping time, exploratory behavior, amphetamine stereotype