Central Inhibitory Activity of the Aqueous Extract of Crinum giganteum
The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD50 in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity.
Crinum giganteum, spontaneous motor activity, pentobarbital sleeping time, exploratory behavior, amphetamine stereotype
Amos, Samson; Binda, L.; Akah, P.; Wambebe, C.; and Gamaniel, K., "Central Inhibitory Activity of the Aqueous Extract of Crinum giganteum" (2003). Pharmaceutical Sciences Faculty Publications. 120.