Anti-nociceptive and Anti-inflammatory Effects of the Methanol Extract of Annona senegalensis Root Bark
Journal of Natural Remedies
Objective: To investigate the antinociceptive and anti-inflammatory effect of Annona senegalensis in mice and rats. Materials and Methods: The analgesic effects of the methanolic extract were studied using acetic acid-induced writhing test, hot plate test and formalin test, while the anti-inflammatory effect was evaluated using the egg-albumin induced hind paw oedema in rats. Results: The methanolic extract exhibited antinociceptive activity against the acetic acid writhing test, hot plate test and the late phase of formaline induced nociception and significant anti-inflammatory activity. Conclusion: The analgesic and anti-inflammatory effect of the methanolic extract might be through peripheral mechanisms and thus justifying its folkloric use in the treatement of rheumatic pain.
Annona senegalensis, analgesia, anti-inflammatory, rheumatism
Adzu, B.; Amos, Samson; Adamu, M.; and Gamaniel, K., "Anti-nociceptive and Anti-inflammatory Effects of the Methanol Extract of Annona senegalensis Root Bark" (2003). Pharmaceutical Sciences Faculty Publications. 121.