"Central Nervous System Activity of the Methanol Extract of <em>Ficus p" by B. A. Chindo, Samson Amos et al.
 

Pharmaceutical Sciences Faculty Publications

Central Nervous System Activity of the Methanol Extract of Ficus platyphylla Stem Bark

Document Type

Article

Publication Date

3-2003

Journal Title

Journal of Ethnopharmacology

ISSN

0378-8741

Volume

85

Issue

1

First Page

131

Last Page

137

DOI

http://dx.doi.org/10.1016/s0378-8741(02)00376-8

PubMed ID

12576211

Abstract

The central nervous system (CNS) activity of the methanolic extract of Ficus platyphylla stem bark was studied on locomotor activity, pentobarbital sleeping time, exploratory behaviour, amphetamine-induced hyperactivity, apomorphine-induced stereotypy, active-avoidance and performance on tread mills (rota-rod), using mice and rats. The results revealed that the extract significantly reduced the locomotor and exploratory activities in mice, prolonged pentobarbital sleeping time in rats, attenuated amphetamine-induced hyperactivity and apomorphine-induced stereotypy in mice, dose-dependently. The extract significantly suppressed the active-avoidance response in rats, with no significant effect on motor co-ordination as determined by the performance on rota-rod. The results suggest that the extract may possess sedative principles with potential neuroleptic properties.

Keywords

Ficus platyphylla, locomotor activity, pentobarbital sleeping time, exploratory behaviour, motor co-ordination, active-avoidance

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