Pharmaceutical Sciences Faculty Publications
Central Nervous System Activity of the Methanol Extract of Ficus platyphylla Stem Bark
Document Type
Article
Publication Date
3-2003
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741
Volume
85
Issue
1
First Page
131
Last Page
137
DOI
http://dx.doi.org/10.1016/s0378-8741(02)00376-8
PubMed ID
12576211
Abstract
The central nervous system (CNS) activity of the methanolic extract of Ficus platyphylla stem bark was studied on locomotor activity, pentobarbital sleeping time, exploratory behaviour, amphetamine-induced hyperactivity, apomorphine-induced stereotypy, active-avoidance and performance on tread mills (rota-rod), using mice and rats. The results revealed that the extract significantly reduced the locomotor and exploratory activities in mice, prolonged pentobarbital sleeping time in rats, attenuated amphetamine-induced hyperactivity and apomorphine-induced stereotypy in mice, dose-dependently. The extract significantly suppressed the active-avoidance response in rats, with no significant effect on motor co-ordination as determined by the performance on rota-rod. The results suggest that the extract may possess sedative principles with potential neuroleptic properties.
Keywords
Ficus platyphylla, locomotor activity, pentobarbital sleeping time, exploratory behaviour, motor co-ordination, active-avoidance
Recommended Citation
Chindo, B. A.; Amos, Samson; Odutola, A. A.; Vongtau, H. O.; Abbah, J.; Wambebe, C.; and Gamaniel, K. S., "Central Nervous System Activity of the Methanol Extract of Ficus platyphylla Stem Bark" (2003). Pharmaceutical Sciences Faculty Publications. 122.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/122
