Pharmaceutical Sciences Faculty Publications

Title

Central Nervous System Activity of the Methanol Extract of Ficus platyphylla Stem Bark

Document Type

Article

Publication Date

3-2003

Journal Title

Journal of Ethnopharmacology

ISSN

0378-8741

Volume

85

Issue

1

First Page

131

Last Page

137

DOI

http://dx.doi.org/10.1016/s0378-8741(02)00376-8

PubMed ID

12576211

Abstract

The central nervous system (CNS) activity of the methanolic extract of Ficus platyphylla stem bark was studied on locomotor activity, pentobarbital sleeping time, exploratory behaviour, amphetamine-induced hyperactivity, apomorphine-induced stereotypy, active-avoidance and performance on tread mills (rota-rod), using mice and rats. The results revealed that the extract significantly reduced the locomotor and exploratory activities in mice, prolonged pentobarbital sleeping time in rats, attenuated amphetamine-induced hyperactivity and apomorphine-induced stereotypy in mice, dose-dependently. The extract significantly suppressed the active-avoidance response in rats, with no significant effect on motor co-ordination as determined by the performance on rota-rod. The results suggest that the extract may possess sedative principles with potential neuroleptic properties.

Keywords

Ficus platyphylla, locomotor activity, pentobarbital sleeping time, exploratory behaviour, motor co-ordination, active-avoidance