Pharmaceutical Sciences Faculty Publications

Title

Neuropharmacological Effect of the Aqueous Extract of Sphaeranthus senegalensis in Mice

Document Type

Article

Publication Date

11-2001

Journal Title

Journal of Ethnopharmacology

ISSN

0378-8741

Volume

78

Issue

1

First Page

33

Last Page

37

DOI

http://dx.doi.org/10.1016/s0378-8741(01)00316-6

PubMed ID

11585685

Abstract

Effects of the aqueous extract of Sphaeranthus senegalensis Vaill. (Family: Compositae) were studied on spontaneous motor activity, exploratory behaviour, rota-rod performance and pentobarbital sleeping time in mice. Preliminary phytochemical evaluation and acute toxicity (LD50) values were also studied. The extract (50 and 100 mg/kg p.o.) produced reduction in spontaneous motor activity, exploratory behaviour and motor coordination and prolonged pentobarbital sleeping time. Glycosides, saponins and tannins were shown to be present in the extract. The i.p. LD50 in mice was 2735.61 and 5000 mg/kg orally. The results suggest that the aqueous extract of S. senegalensiscontains some active principles, which may be sedative in nature.

Keywords

Sphaeranthus senegalensis, sedation, spontaneous motor activity, exploratory behaviour, motor coordination, pentobarbital sleeping time