Pharmaceutical Sciences Faculty Publications

Title

Pharmacological Evidence Favouring the Folkloric Use of Diospyros mespiliformis Hochst in the Relief of Pain and Fever

Document Type

Article

Publication Date

10-2002

Journal Title

Journal of Ethnopharmacology

ISSN

0378-8741

Volume

82

Issue

2-3

First Page

191

Last Page

195

DOI

http://dx.doi.org/10.1016/s0378-8741(02)00179-4

PubMed ID

12241995

Abstract

The methanol extract of Diospyros mespiliformis was evaluated for its claimed folkloric usage in the relief of pain and fever. Antipyretic, analgesic and anti-inflammatory effects of the extract were evaluated in rats and mice. Studies were carried out on yeast-induced pyrexia in rats, acetic acid-induced writhing in mice, formalin test and egg albumin-induced anti-inflammatory activity in rats. The extract (50 and 100 mg/kg i.p.) gave a potent antipyretic effect for 100 mg/kg and significant activity (P<0.05) against all the analgesic and anti-inflammatory models used. The LD50 of the extract was estimated to be 513.80±33.92 mg/kg i.p. in mice. These results provide support for the use of the plant in relieving pain and fever.

Keywords

Diospyros mespiliformis, antipyretic, analgesic, anti-inflammatory