Pharmaceutical Sciences Faculty Publications

Title

The Pharmacological Effects of an Aqueous Extract from Acacia nilotica Seeds

Document Type

Article

Publication Date

12-1999

Journal Title

Phytotherapy Research

ISSN

0951-418X

Volume

13

Issue

8

First Page

683

Last Page

685

DOI

http://dx.doi.org/10.1002/(sici)1099-1573(199912)13:8<683::aid-ptr534>3.0.co;2-x

PubMed ID

10594939

Abstract

An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 µg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.

Keywords

Acacia nilotica, spasmogenic activity, blood pressure elevation, folk medicine, calcium