Pharmaceutical Sciences Faculty Publications

Title

Antinociceptive Activity of Zizyphus spina-christi Root Bark Extract

Document Type

Article

Publication Date

5-2001

Journal Title

Fitoterapia

ISSN

0367-326X

Volume

72

Issue

4

First Page

344

Last Page

350

DOI

http://dx.doi.org/10.1016/s0367-326x(00)00289-6

PubMed ID

11395256

Abstract

The antinociceptive effect of the aqueous extract of Zizyphus spina-christi root bark was investigated in mice and rats. Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD50 in mice was 2236.07 mg/kg.

Keywords

Zizyphus spina-christi, Antinociceptive activity

Comments

Journal also known as Fitoterapia: The Journal for the Study of Medicinal Plants