Pharmaceutical Sciences Faculty Publications

Title

Spasmolytic Activity of Methyl Angolensate: A Triterpenoid Isolated from Entandrophragma angolense

Document Type

Article

Publication Date

4-2001

Journal Title

Biological and Pharmaceutical Bulletin

ISSN

0918-6158

Volume

24

Issue

4

First Page

364

Last Page

367

DOI

http://dx.doi.org/10.1248/bpb.24.364

PubMed ID

11305596

Abstract

Entandrophragma angolense is a medicinal plant used in folk medicine against several diseases including peptic ulcer. Methyl angolensate was isolated from E. angolense by recrystallization from methanol. The needlelike crystals were characterized and tested on isolated rabbit jejunum, guinea pig ileum and the rat fundus strip. The compound was also evaluated on the gastrointestinal transit in mice. The results showed that the compound exerted significant concentration dependent inhibition of smooth muscle and reduced the propulsive action of the gastrointestinal tract in mice. The relaxation observed did not attenuate acetylcholine and histamine induced contractions, but was found to inhibit contractions induced by serotonin. It is therefore suggested that methyl angolensate may exert its activity on gastrointestinal smooth muscle via serotonergic mechanisms.

Keywords

Entandrophragma angolense, methyl angolensate, smooth muscle, serotonin