Pharmaceutical Sciences Faculty Publications
Spasmolytic Activity of Methyl Angolensate: A Triterpenoid Isolated from Entandrophragma angolense
Document Type
Article
Publication Date
4-2001
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158
Volume
24
Issue
4
First Page
364
Last Page
367
DOI
http://dx.doi.org/10.1248/bpb.24.364
PubMed ID
11305596
Abstract
Entandrophragma angolense is a medicinal plant used in folk medicine against several diseases including peptic ulcer. Methyl angolensate was isolated from E. angolense by recrystallization from methanol. The needlelike crystals were characterized and tested on isolated rabbit jejunum, guinea pig ileum and the rat fundus strip. The compound was also evaluated on the gastrointestinal transit in mice. The results showed that the compound exerted significant concentration dependent inhibition of smooth muscle and reduced the propulsive action of the gastrointestinal tract in mice. The relaxation observed did not attenuate acetylcholine and histamine induced contractions, but was found to inhibit contractions induced by serotonin. It is therefore suggested that methyl angolensate may exert its activity on gastrointestinal smooth muscle via serotonergic mechanisms.
Keywords
Entandrophragma angolense, methyl angolensate, smooth muscle, serotonin
Recommended Citation
Orisadipe, A.; Amos, Samson; Adesomoju, A.; Binda, L.; Emeje, M.; Okogun, J.; Wambebe, C.; and Gamaniel, K., "Spasmolytic Activity of Methyl Angolensate: A Triterpenoid Isolated from Entandrophragma angolense" (2001). Pharmaceutical Sciences Faculty Publications. 136.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/136
