Pharmaceutical Sciences Faculty Publications

Title

Behavioral Effects of the Aqueous Extract of Guiera senegalensis in Mice and Rats

Document Type

Article

Publication Date

2001

Journal Title

Phytomedicine

ISSN

0944-7113

Volume

8

Issue

5

First Page

356

Last Page

361

DOI

http://dx.doi.org/10.1078/0944-7113-00056

PubMed ID

11695878

Abstract

Behavioral effects of the aqueous extract of Guiera senegalensis on the central nervous system of mice and rats were investigated. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behavior, exploratory activity and performance on treadmills (rota-rod) were evaluated. The results revealed that the aqueous extract ofG. senegalensis reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behavior in rats. The extract also decreased exploratory activity in mice and had no observable effects on motor coordination (rota-rod) at the doses tested. The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature.

Keywords

G. senegalensis, gross behavior, pentobarbital sleep, motor coordination, exploratory activity

Comments

Journal also known as Phytomedicine: International Journal of Phytotherapy and Phytopharmacology