Pharmaceutical Sciences Faculty Publications

Title

Anti-sickling, Analgesic and Anti-inflammatory Properties of 3,5-Dimethoxy-4-Hydroxy Benzoic Acid and 2,3,4-Trihydroxyacetophenone

Document Type

Article

Publication Date

4-2000

Journal Title

Phytomedicine

ISSN

0944-7113

Volume

7

Issue

2

First Page

105

Last Page

110

DOI

http://dx.doi.org/10.1016/s0944-7113(00)80081-1

PubMed ID

10839212

Abstract

Effects of 3, 5 - dimethoxy - 4 - hydroxybenzoic acid and 2, 3, 4 - trihydroxyacetophenone were studied on haemoglobin S (Hb S) polymerisation, analgesia and inflammation using Hb S solution, rats and mice. UV spectrophotometric procedure was used to monitor the polymerization of the Hb S. Acetic acid induced writhing in mice and egg albumin induced rat paw edema procedures were used to evaluate analgesic and anti-inflammatory activities of the compounds respectively. The results indicate that both drugs inhibit the process of polymerization significantly, possibly by direct action on the Hb S molecules. The drugs inhibited acetic acid induced pain and decreased egg albumin induced oedema. It is concluded that 3, 5 - dimethoxy - 4 - hydroxybenzoic acid and 2, 3, 4 - trihydroxyacetophenone may have some value in the management of sickle cell disease.

Keywords

3, 5 - dimethoxy - 4 - hydroxybenzoic acid, 2', 3', 4'-trihydroxyacetophenone, haemoglobin S, anti-sickling, analgesia, inflammation

Comments

Journal also known as Phytomedicine: International Journal of Phytotherapy and Phytopharmacology