Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells

Authors

Rocco J. Rotello, Cedarville UniversityFollow
Rita C. Lieberman, University of Colorado
Anthony F. Purchio, Oncogen
Lazaro E. Gerschenson, University of Colorado

Document Type

Article

Publication Date

4-15-1991

Journal Title

Proceedings of the National Academy of Sciences

Volume

88

Issue

8

First Page

3412

Last Page

3415

DOI

http://dx.doi.org/10.1073/pnas.88.8.3412

PubMed ID

2014262

PubMed Central® ID

PMC51457

Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

Keywords

Apoptosis

Recommended Citation

Rotello, Rocco J.; Lieberman, Rita C.; Purchio, Anthony F.; and Gerschenson, Lazaro E., "Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells" (1991). Pharmaceutical Sciences Faculty Publications. 65.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/65