Pharmaceutical Sciences Faculty Publications

Title

Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells

Document Type

Article

Publication Date

4-15-1991

Journal Title

Proceedings of the National Academy of Sciences

Volume

88

Issue

8

First Page

3412

Last Page

3415

DOI

http://dx.doi.org/10.1073/pnas.88.8.3412

PubMed ID

2014262

PubMed Central® ID

PMC51457

Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

Keywords

Apoptosis