Pharmaceutical Sciences Faculty Publications

Title

Prevention of Vertebrate Neuronal Death by the crmA Gene

Document Type

Article

Publication Date

2-11-1994

Journal Title

Science

Volume

263

Issue

5148

First Page

826

Last Page

828

DOI

http://dx.doi.org/10.1126/science.8303301

PubMed ID

8303301

Abstract

Interleukin-1β converting enzyme (ICE) is a mammalian homolog of CED-3, a protein required for programmed cell death in the nematode Caenorhabditis elegans. The activity of ICE can be specifically inhibited by the product of crmA, a cytokine response modifier gene encoded by cowpox virus. Microinjection of the crmA gene into chicken dorsal root ganglion neurons was found to prevent cell death induced by deprivation of nerve growth factor. Thus, ICE is likely to participate in neuronal death in vertebrates.

Keywords

CrmA, genes, genetics