Pharmacy Practice Faculty Publications

Title

Leukotriene Modifiers in the Management of Asthma

Document Type

Article

Publication Date

7-1999

Journal Title

The Journal of the American Osteopathic Association

ISSN

0098-6151

Volume

99

Issue

7 (Supplement)

First Page

S1

Last Page

S6

PubMed ID

10478513

Abstract

Leukotrienes play a major role in the underlying pathophysiology of asthma. Leukotriene-receptor antagonists and direct leukotriene-synthesis inhibitors may be important new agents in maintenance therapy for asthma. Their role may also extend to attenuating exercise-induced and allergen-induced bronchospasm. This article reviews the effectiveness of available leukotriene modifiers in various clinical studies, reviews their adverse effects profile, and discusses their potential roles in the management of asthma.

Keywords

Asthma, therapy, medications, adverse effects, leukotriene antagonists