Science and Mathematics Faculty Publications

Title

Design and Synthesis of an Activity-Based Probe Template for Protein Kinases

Document Type

Article

Publication Date

2010

Journal Title

Synlett

Volume

2010

Issue

4

First Page

521

Last Page

524

Abstract

A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor ­kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.

Keywords

activity-based probes, addition reactions, regioselectivity, enones, epoxides

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