Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
1. The present study has evaluated, in vitro, alpha 1-adrenergic receptor mediated responses in submandibular cells from young adult and aged rats.
2. Submandibular glands from different aged rats possess a similar number of alpha 1-adrenergic receptors that display comparable binding characteristics.
3. Following alpha 1-adrenergic stimulation, cells from both groups of rats show a similar ability to mobilize intracellular Ca2+ (45Ca2+ time course, agonist dose-response) and to elicit a functional response (inhibition of protein synthesis by epinephrine) which reflects Ca2+ mobilization.
Adrenergic, submandibular gland, rats, calcium, epinephrine, prazosin, receptors
Baum, B. J.; Kuyatt, Brian L.; Helman, Y.; Gee, M. V.; and Roth, G. S., "Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro" (1985). Center for Teaching and Learning Publications. 5.