Low Dose Nicotine Exposure Improves Posterior Spinal Fusion in an In Vivo Rabbit Model

Authors

John C. France
Scott D. Daffner
Chad Smalley
Stacey Waugh
Timothy L. Norman, Cedarville UniversityFollow
Nina Clovis
Suzanne Smith
Vincent Kish
Nilay Mukherjee

Document Type

Conference Proceeding

Publication Date

10-2009

Journal Title

The Spine Journal

Volume

9

Issue

10

First Page

12S

DOI

http://dx.doi.org/10.1016/j.spinee.2009.08.029

Abstract

BACKGROUND CONTEXT: A previous pilot study by our group demonstrated that nicotine administration via transdermal nicotine patch showed consistent serum nicotine levels whereas administration via the more commonly utilized mini-osmotic pump resulted in large variations in serum levels of nicotine of rabbits. In other work, we have previously demonstrated that nicotine delivered via a transdermal patch enhanced posterior spinal fusion rates in rabbits. This is contrary to studies published by other groups where nicotine administration decreased fusion rates.

Recommended Citation

France, John C.; Daffner, Scott D.; Smalley, Chad; Waugh, Stacey; Norman, Timothy L.; Clovis, Nina; Smith, Suzanne; Kish, Vincent; and Mukherjee, Nilay, "Low Dose Nicotine Exposure Improves Posterior Spinal Fusion in an In Vivo Rabbit Model" (2009). Engineering and Computer Science Faculty Publications. 245.
https://digitalcommons.cedarville.edu/engineering_and_computer_science_publications/245