Nicotine Increases Osteoblast Activity in In Vitro Cell Culture in a Dose Dependent Manner
The Spine Journal
BACKGROUND CONTEXT: Prior studies by our group have shown that nicotine delivered via a transdermal nicotine patch significantly enhanced posterior spinal fusion rates in rabbits. This runs contrary to previously published studies by other groups in which nicotine administration decreased fusion rates. Hence, there may be a dose-dependent effect of nicotine on posterior spinal fusion outcomes.
Daffner, Scott D.; France, John; Smalley, Chad; Waugh, Stacey; Norman, Timothy L.; Clovis, Nina; Smith, Suzanne; Kish, Vincent; and Mukherjee, Nilay, "Nicotine Increases Osteoblast Activity in In Vitro Cell Culture in a Dose Dependent Manner" (2009). Engineering and Computer Science Faculty Publications. 246.