Pharmaceutical Sciences Faculty Publications

Anti-nociceptive and Anti-inflammatory Effects of the Methanol Extract of Annona senegalensis Root Bark

Document Type

Article

Publication Date

1-2003

Journal Title

Journal of Natural Remedies

Volume

3

Issue

1

First Page

63

Last Page

67

Abstract

Objective: To investigate the antinociceptive and anti-inflammatory effect of Annona senegalensis in mice and rats. Materials and Methods: The analgesic effects of the methanolic extract were studied using acetic acid-induced writhing test, hot plate test and formalin test, while the anti-inflammatory effect was evaluated using the egg-albumin induced hind paw oedema in rats. Results: The methanolic extract exhibited antinociceptive activity against the acetic acid writhing test, hot plate test and the late phase of formaline induced nociception and significant anti-inflammatory activity. Conclusion: The analgesic and anti-inflammatory effect of the methanolic extract might be through peripheral mechanisms and thus justifying its folkloric use in the treatement of rheumatic pain.

Keywords

Annona senegalensis, analgesia, anti-inflammatory, rheumatism

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