The Pharmacological Effects of an Aqueous Extract from Acacia nilotica Seeds
An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 µg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.
Acacia nilotica, spasmogenic activity, blood pressure elevation, folk medicine, calcium
Amos, Samson; Akah, P. A.; Odukwe, C. J.; Gamaniel, K. S.; and Wambede, C., "The Pharmacological Effects of an Aqueous Extract from Acacia nilotica Seeds" (1999). Pharmaceutical Sciences Faculty Publications. 132.