Pharmaceutical Sciences Faculty Publications
The Pharmacological Effects of an Aqueous Extract from Acacia nilotica Seeds
Document Type
Article
Publication Date
12-1999
Journal Title
Phytotherapy Research
ISSN
0951-418X
Volume
13
Issue
8
First Page
683
Last Page
685
DOI
http://dx.doi.org/10.1002/(sici)1099-1573(199912)13:8<683::aid-ptr534>3.0.co;2-x
PubMed ID
10594939
Abstract
An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 µg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.
Keywords
Acacia nilotica, spasmogenic activity, blood pressure elevation, folk medicine, calcium
Recommended Citation
Amos, Samson; Akah, P. A.; Odukwe, C. J.; Gamaniel, K. S.; and Wambede, C., "The Pharmacological Effects of an Aqueous Extract from Acacia nilotica Seeds" (1999). Pharmaceutical Sciences Faculty Publications. 132.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/132
