Pharmaceutical Sciences Faculty Publications
COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models
Document Type
Article
Publication Date
6-25-2014
Journal Title
Science Translational Medicine
ISSN
1946-6242
Volume
6
Issue
242
First Page
242
Last Page
242
DOI
https://doi.org/10.1126/scitranslmed.3008455
PubMed ID
24964992
Abstract
Antiangiogenic agents that block vascular endothelial growth factor (VEGF) signaling are important components of current cancer treatment modalities but are limited by alternative ill-defined angiogenesis mechanisms that allow persistent tumor vascularization in the face of continued VEGF pathway blockade. We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. PGE2 production in preclinical breast and colon cancer models was tightly controlled by cyclooxygenase-2 (COX-2) expression, and COX-2 inhibition augmented VEGF pathway blockade to suppress angiogenesis and tumor growth, prevent metastasis, and increase overall survival. These results demonstrate the importance of the COX-2/PGE2 pathway in mediating resistance to VEGF pathway blockade and could aid in the rapid development of more efficacious anticancer therapies.
Keywords
Inhibitors, cell line, tumor, clone cells, liver neoplasms
Recommended Citation
Xu, Lihong; Stevens, Janine; Hilton, Mary Beth; Seaman, Steven; Conrads, Thomas P.; Veenstra, Timothy D.; Logsdon, Daniel; Morris, Holly; Swing, Deborah A; Patel, Nimit L.; Kalen, Joseph; Haines, Diana C.; Zudaire, Enrique; and St. Croix, Brad, "COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models" (2014). Pharmaceutical Sciences Faculty Publications. 182.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/182
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
