Pharmaceutical Sciences Faculty Publications

Title

Neuroproteomic Tools for Battling Alzheimer's Disease

Document Type

Article

Publication Date

11-1-2016

Journal Title

Proteomics

ISSN

1615-9861

Volume

16

Issue

22

First Page

2847

Last Page

2853

DOI

10.1002/pmic.201600211

PubMed ID

27633846

Abstract

With the life expectancy of individuals in the developed nations reaching historic highs, the incidence of dementia within the aging population is also increasing. Of the known causes of dementia, the major culprit is Alzheimer's disease (AD). The numbers of individuals suffering from AD is expected to nearly triple over the next 35 years unless medical science can identify better methods for diagnosing and treating AD. Fortunately, proteomics technologies have not only rapidly matured in the past few decades but also have been effectively applied so that the biomarkers of AD can be more effectively vetted and analyzed. The effectiveness of the technologies described in this paper enable the efficacy of drugs aimed at treating AD to be tested much faster than the previously possible and enable the more accurate selection of patients that are suitable for clinical trials.

Keywords

Alzheimer Disease, Amyloid beta-Peptides, Animals, Drug Discovery, Humans, Mass Spectrometry, Molecular Targeted Therapy, Proteomics

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