Quantitation of Nanoparticles in Serum Matrix by Capillary Electrophoresis
Methods in Molecular Biology: Characterization of Nanoparticles Intended for Drug Delivery
Sensitive and fast analytical techniques are needed to determine the concentration of nanoparticles in biological samples (e.g., blood and tissues) for biodistribution and toxicity studies. This chapter describes a method for the use of capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) for the quantitation of fullerene nanoparticles in human serum matrix. Data on the fullerene-based nanoparticle carboxyfullerene (C3 fullerene) in human serum is presented as an example.
Calibration, chromatography, electrophoresis, capillary, nanoparticles, serum, tissue distribution
Chan, King C.; Veenstra, Timothy D.; and Issaq, Haleem J., "Quantitation of Nanoparticles in Serum Matrix by Capillary Electrophoresis" (2011). Pharmaceutical Sciences Faculty Publications. 254.