Pharmaceutical Sciences Faculty Publications

Title

Quantitation of Nanoparticles in Serum Matrix by Capillary Electrophoresis

Document Type

Article

Publication Date

1-1-2011

Journal Title

Methods in Molecular Biology: Characterization of Nanoparticles Intended for Drug Delivery

ISSN

1940-6029

Volume

697

First Page

145

Last Page

153

DOI

10.1007/978-1-60327-198-1_15

PubMed ID

21116963

Abstract

Sensitive and fast analytical techniques are needed to determine the concentration of nanoparticles in biological samples (e.g., blood and tissues) for biodistribution and toxicity studies. This chapter describes a method for the use of capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) for the quantitation of fullerene nanoparticles in human serum matrix. Data on the fullerene-based nanoparticle carboxyfullerene (C3 fullerene) in human serum is presented as an example.

Keywords

Calibration, chromatography, electrophoresis, capillary, nanoparticles, serum, tissue distribution

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