Pharmaceutical Sciences Faculty Publications
Utility of separation science in metabolomic studies.
Document Type
Article
Publication Date
6-1-2008
Journal Title
Journal of Separation Science
ISSN
1615-9314
Volume
31
Issue
11
First Page
1936
Last Page
1947
DOI
10.1002/jssc.200700601
PubMed ID
18348322
Abstract
Metabolomics, or alternately metabonomics, an emerging field of biochemical research, is a complementary technique to genomics, transcriptomics, and proteomics. Direct quantitative measurements of metabolite expressions in urine, serum, plasma, and tissue are essential for the study of biological processes in normal and disease states. Since the number of metabolites in a biological sample is large separation science plays an important role in metabolomic research. This review describes the role of GC, HPLC, CE, and supercritical fluid chromatography in metabolomic research. The application of each technique is discussed and its advantages and limitations are discussed with selective illustrative examples.
Keywords
Animals, biomarkers, chemistry techniques, analytical, chromatography, humans, mass spectrometry, metabolism
Recommended Citation
Issaq, Haleem J.; Abbott, Eric; and Veenstra, Timothy D., "Utility of separation science in metabolomic studies." (2008). Pharmaceutical Sciences Faculty Publications. 330.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/330
