Pharmaceutical Sciences Faculty Publications

Analysis of Biofluids for Biomarker Research

Document Type

Article

Publication Date

10-1-2008

Journal Title

Proteomics Clinical Applications

ISSN

1862-8346

Volume

2

Issue

10-11

First Page

1403

Last Page

1412

DOI

10.1002/prca.200780173

PubMed ID

21136789

Abstract

While many of the developments made in high-throughput proteomics were originally applied to procaryotic and simple eucaryotic organisms, the analysis of biofluids became increasingly important as the prospect of using proteomics to discover novel biomarkers became realized. Biofluids have represented a unique challenge to proteomics as they are often present only in small amounts and, particularly in the cases of serum and plasma, can have protein concentration ranges that differ by ten orders of magnitude. While the discovery of authentic, clinically useful biomarkers in the proteomics era has been lacking, there have been a number of significant developments in the ability to more comprehensively characterize biofluid proteomes. The rapid pace of these developments suggest that the eventual discovery of clinically validate biomarkers using proteomic technologies still has a bright future.

Keywords

Biofluids, biomarkers, research, proteomics

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