Pharmaceutical Sciences Faculty Publications

Title

Proteomic Analysis of Traumatic Brain Injury: The Search for Biomarkers

Document Type

Article

Publication Date

4-1-2008

Journal Title

Expert Review of Proteomics

ISSN

1744-8387

Volume

5

Issue

2

First Page

283

Last Page

291

DOI

10.1586/14789450.5.2.283

PubMed ID

18466057

Abstract

Although there are a number of causes of traumatic brain injury (TBI), the armed conflict in Iraq and Afghanistan has brought this disorder to the attention of the global community. A biomarker that would enable army medics to rapidly diagnose the severity of TBI on the battle-field would be a huge asset. Unfortunately, the study of TBI has not historically attracted the proteomic research community's interest as other disorders have, such as cancer. On the positive side, however, many of the analytical and technological challenges that were overcome in the development of biofluid proteomic methods are now being applied to the study of TBI. In this review, we discuss and highlight select examples of discovery-driven proteomic studies focused on finding effective biomarkers for TBI.

Keywords

Biomarkers, brain injuries, humans, proteins, proteomics, trauma severity indices

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