Pharmaceutical Sciences Faculty Publications

Document Type

Article

Publication Date

6-1-2005

Journal Title

BioTechniques

ISSN

0736-6205

Volume

38

Issue

6S

First Page

32

Last Page

35

DOI

10.2144/05386su06

PubMed ID

16528915

Abstract

Identification and quantitation of candidate biomarker proteins in large numbers of individual tissues is required to validate specific proteins, or panels of proteins, for clinical use as diagnostic, prognostic, toxicological, or therapeutic markers. Mass spectrometry (MS) provides an exciting analytical methodology for this purpose. Liquid Tissue MS protein preparation allows researchers to utilize the vast, already existing, collections offormalin-fixed paraffin-embedded (FFPE) tissues for the procurement of peptides and the analysis across a variety of MS platforms.

Keywords

Chromatography, liquid, colonic neoplasms, formaldehyde, mass spectrometry, neoplasm proteins, paraffin embedding, proteomics, tissue fixation

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