Pharmaceutical Sciences Faculty Publications

Title

Lessons from Kitty Hawk: From Feasibility to Routine Clinical Use for the Field of Proteomic Pattern Diagnostics

Document Type

Article

Publication Date

8-1-2004

Journal Title

Proteomics

ISSN

1615-9853

Volume

4

Issue

8

First Page

2357

Last Page

2360

DOI

10.1002/pmic.200400865

PubMed ID

15274129

Abstract

Proteomic pattern diagnostics is a rapidly evolving field of science. Despite the increasingly large number of laboratories reporting exciting success with this concept, recent speculation concerning reproducibility and the nature and identities of the information content of the pattern constituents have served to defocus and polarize the community. These controversies will be rendered obsolete as the field accelerates into a new realm of clinical diagnostics. This new era will see the currently dry biomarker pipeline flooded with new candidate molecules, and the mass spectrometer will continue its maturation into a dominant clinical platform. We reflect on the important lessons gleaned from the Wright brothers' attempts at controlled heavier-than-air flight as a model for perseverance and a view to the very near future for proteomic pattern diagnostics.

Keywords

Biomarkers, diagnostic techniques and procedures, humans, proteomics

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