Pharmaceutical Sciences Faculty Publications

Title

Sheathless Electrospray Ionization Interfaces for Capillary Electrophoresis-Mass Spectrometric Detection Advantages and Limitations

Document Type

Article

Publication Date

10-22-2004

Journal Title

Journal of Chromatography A

ISSN

0021-9673

Volume

1053

Issue

1-2

First Page

37

Last Page

42

DOI

15543970

Abstract

A review of sheathless interfaces for capillary electrophoresis (CE)-mass spectrometry (MS) is presented. The review discusses the on-line CE-MS system requirements, advantages and weaknesses of current sheathless interface designs for CE-electrospray ionization MS, and comparison between sheath flow and sheathless interfaces. The advantages and limitations of three sheathless designs are discussed and commented upon, these include single-capillary, two-capillary and three-piece designs.

Keywords

Electrophoresis, capillary, spectrometry, mass, electrospray ionization

Share

COinS