High-resolution serum proteomic features for ovarian cancer detection.
Serum proteomic pattern diagnostics is an emerging paradigm employing low-resolution mass spectrometry (MS) to generate a set of biomarker classifiers. In the present study, we utilized a well-controlled ovarian cancer serum study set to compare the sensitivity and specificity of serum proteomic diagnostic patterns acquired using a high-resolution versus a low-resolution MS platform. In blinded testing sets, the high-resolution mass spectral data contained multiple diagnostic signatures that were superior to the low-resolution spectra in terms of sensitivity and specificity (P
Biomarkers, tumor, blood proteins, diagnosis, differential, neoplasm proteins, ovarian neoplasms, proteomics, spectrometry, mass
Conrads, T. P.; Fusaro, V. A.; Ross, S.; Johann, D.; Rajapakse, V.; Hitt, B. A.; Steinberg, S. M.; Kohn, E. C.; Fishman, D. A.; Veenstra, Timothy D.; and et al, "High-resolution serum proteomic features for ovarian cancer detection." (2004). Pharmaceutical Sciences Faculty Publications. 466.