Pharmaceutical Sciences Faculty Publications

Title

High-resolution serum proteomic features for ovarian cancer detection.

Document Type

Article

Publication Date

6-1-2004

Journal Title

Endocrine-Related Cancer

ISSN

1351-0088

Volume

11

Issue

2

First Page

163

Last Page

178

DOI

10.1677/erc.0.0110163

PubMed ID

15163296

Abstract

Serum proteomic pattern diagnostics is an emerging paradigm employing low-resolution mass spectrometry (MS) to generate a set of biomarker classifiers. In the present study, we utilized a well-controlled ovarian cancer serum study set to compare the sensitivity and specificity of serum proteomic diagnostic patterns acquired using a high-resolution versus a low-resolution MS platform. In blinded testing sets, the high-resolution mass spectral data contained multiple diagnostic signatures that were superior to the low-resolution spectra in terms of sensitivity and specificity (P

Keywords

Biomarkers, tumor, blood proteins, diagnosis, differential, neoplasm proteins, ovarian neoplasms, proteomics, spectrometry, mass

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