Pharmaceutical Sciences Faculty Publications

Title

Cancer Diagnosis Using proteomic Patterns

Document Type

Article

Publication Date

7-1-2003

Journal Title

Expert Review of Molecular Diagnostics

ISSN

1473-7159

Volume

3

Issue

4

First Page

411

Last Page

420

DOI

10.1586/14737159.3.4.411

PubMed ID

12877381

Abstract

The advent of proteomics has brought with it the hope of discovering novel biomarkers that can be used to diagnose diseases, predict susceptibility and monitor progression. Much of this effort has focused upon the mass spectral identification of the thousands of proteins that populate complex biosystems such as serum and tissues. A revolutionary approach in proteomic pattern analysis has emerged as an effective method for the early diagnosis of diseases such as ovarian cancer. Proteomic pattern analysis relies on the pattern of proteins observed and does not rely on the identification of a traceable biomarker. Hundreds of clinical samples per day can be analyzed utilizing this technology, which has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.

Keywords

Biomarkers, tumor, gene expression profiling, humans, mass spectrometry, molecular diagnostic techniques, neoplasms, protein array analysis, proteome, proteomics

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