Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells
Proceedings of the National Academy of Sciences
PubMed Central® ID
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
Rotello, Rocco J.; Lieberman, Rita C.; Purchio, Anthony F.; and Gerschenson, Lazaro E., "Coordinated Regulation of Apoptosis and Cell Proliferation by Transforming Growth ß1 in Cultured Uterine Epithelial Cells" (1991). Pharmaceutical Sciences Faculty Publications. 65.