Impact of Obesity on Fosphenytoin Volume of Distribution in Pediatric Patients.
Journal of Child Neurology
The impact of body habitus on fosphenytoin pharmacokinetics is poorly understood in pediatric patients. This retrospective, single-center review examined differences in fosphenytoin volume of distribution (VD) between children with normal and obese body habitus. From 2013 to 2015, patients 2 to 18 years of age who received a loading dose of fosphenytoin were identified. Thirty-seven patients met inclusion criteria. Mean total serum phenytoin concentration was 25.3 ± 6.5 μg/mL in the nonobese group and 29.5 ± 7.6 μg/mL in the obese group ( P = .09). VD was not significantly different between obese and nonobese groups, 0.92 ± 0.26 L/kg and 0.97 ± 0.48 L/kg ( P = .76), respectively. In contrast to adult studies, these data suggest that fosphenytoin dose adjustments for obese children may be unnecessary.
Antiepileptic drugs, children, pediatric, status epilepticus, treatment
Prusakov, Ashley B; Patel, Anup D; and Cole, Justin W., "Impact of Obesity on Fosphenytoin Volume of Distribution in Pediatric Patients." (2018). Pharmacy Practice Faculty Publications. 358.