Design and Synthesis of an Activity-Based Probe Template for Protein Kinases
A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.
activity-based probes, addition reactions, regioselectivity, enones, epoxides
Howell, Amy; Keshipeddy, Santosh; Shi, Yu; Hnatiuk, Nathan E.; Morton, Martha; and Yao, Xudong, "Design and Synthesis of an Activity-Based Probe Template for Protein Kinases" (2010). Science and Mathematics Faculty Publications. 124.