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Addresses of All Authors

Joseph Francis and Matthew Ingle, The Master's University 21726 Placerita Santa Clarita, California 91321

Todd Wood, Core Academy of Science P.O. Box 1076, Dayton, TN 37321

Author's Biography

Joseph Francis is a professor of biology at the Master’s University and assistant professor of general studies at Liberty University. His research interests and publications are in the areas of general biology, invertebrate biology, microbiology, immunology, biology teaching, and bioethics. He currently serves as the dean of the school of science, mathematics, technology and health at the Master’s University. He also serves as a board member of the Creation Biology Society.

Matthew Ingle is an Associate Professor at The Master’s University in Santa Clarita, CA. He teaches courses in several areas of biology, and researches the interaction between parasites and hosts. Matthew has published two papers on parasite origins in Answers Research Journal, and has published in the International Journal of Parasitology.

Todd Charles Wood is the president of Core Academy of Science. He holds a Ph.D. in biochemistry and has done postdoctoral work in genomics. His research interests include created kinds and comparative biology.

Abstract

Much of the research on viruses has concentrated on their disease causing ability. The creation model biomatrix theory predicts that viruses play a beneficial role in cells and organisms. In this report we present a new theory which proposes that mammalian phages (bacteriophages), the most abundant organism associated with mammals, guard and regulate growth of the mammalian microbiome. We base this theory on nearly a century of published evidence that demonstrates that phage can insert into the bacterial genome and cover the surface of bacteria. We propose that this “cloaking” of the bacterial cell surface is an elegant mechanism whereby the normal flora bacteria are protected from immune detection and pathogenic bacteria can be directly lysed by the same phage. Additionally, both phage genome integration and cloaking can be used to prevent normal flora bacteria from conversion to a pathogenic state. Further support for the phage cloaking aspect of our theory has been demonstrated in recent studies which show that phage proteins bind specifically to microbial-associated molecular patterns (MAMPs), which are known to be the major ligands that activate the mammalian immune system. Although these phenomena have been documented separately over decades, we postulate for the first time that these functions work together to promote the integrity of the mammalian microbiome.

Disciplines

Bacteriology | Virology

Keywords

Virus, bacteriophage, virome, microbiome, biomatrix, bacteriome, phage

DOI

https://doi.org/10.15385/jpicc.2018.8.1.16

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