Pharmaceutical Sciences Faculty Presentations
Novel Opioids Based on Salvinorin A
Document Type
Poster Session
Event Date
2008
Conference/Event
International Narcotics Research Conference
Location
Charleston, SC
Abstract
The Mexican mint Salvia divinorum (Lamiaceae) has been gaining legal attention due to its hallucinogenic effects. These effects have been attributed to salvinorin A, a major metabolite of this plant. Synthetic modifications of the selective kappa opioid receptor agonist salvinorin A has yielded full and partial opioid receptor agonists as well as antagonists at the kappa opioid receptor. Studies have shown that salvinorin A induced conditioned place aversion in different animal models. Salvinorin A affects drug-seeking behavior and therefore provides a template for the development of drugs with therapeutic utility in the treatment of stimulant abuse and dependence. The structure-activity relationship studies of novel analogues of salvinorin A and their syntheses will be presented.
Keywords
Opioids, salvinorin A, pharmacy
Recommended Citation
Simpson, Denise S.; Lozama, Anthony; Parrish, Damon; Deschamps, Jeffrey R.; Dersch, Christina M.; Rothman, Richard B.; and Prisinzano, Thomas E., "Novel Opioids Based on Salvinorin A" (2008). Pharmaceutical Sciences Faculty Presentations. 48.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_presentations/48
