Pharmaceutical Sciences Faculty Presentations

Novel Opioids Based on Salvinorin A

Document Type

Poster Session

Event Date



International Narcotics Research Conference


Charleston, SC


The Mexican mint Salvia divinorum (Lamiaceae) has been gaining legal attention due to its hallucinogenic effects. These effects have been attributed to salvinorin A, a major metabolite of this plant. Synthetic modifications of the selective kappa opioid receptor agonist salvinorin A has yielded full and partial opioid receptor agonists as well as antagonists at the kappa opioid receptor. Studies have shown that salvinorin A induced conditioned place aversion in different animal models. Salvinorin A affects drug-seeking behavior and therefore provides a template for the development of drugs with therapeutic utility in the treatment of stimulant abuse and dependence. The structure-activity relationship studies of novel analogues of salvinorin A and their syntheses will be presented.


Opioids, salvinorin A, pharmacy