Pharmaceutical Sciences Faculty Presentations

Postsynaptic Dopamine (D2)-Receptor May be Involved in the Behavioral Activities of Artemisinin in Rodents

Document Type

Abstract

Event Date

2003

Conference/Event

International Society for Neurochemistry Biennial Meeting

Abstract

Behavioural effects of Artemisinin (AR) were studied on spontaneous motor activity (SMA), exploratory behaviour (EB), apomorphine induced stereo- typed behaviour (ASB) in mice and bromocriptine induced hyperactivity (BIH) in short-term reserpinized(STR) mice. AR (50 and 100 mg/kg, i.p.) significantly (p < 0.05) reduced the SMA, EB and attenuated ASB mice. The STR Mice showed a decreased in locomotor activity (LA), which was activated by bromocriptine (5 mg/kg, i.p.). AR attenuated BIH in the STR mice. The results suggest that artemisinin possesses central inhibitory property, which may be mediated via postsynaptic dopamin E (D2)-receptor antagonism in the brain stem area.

Keywords

Artemisinin, behavior, brain stem, bromocriptine, dopaminereceptor

Comments

Abstract for poster presentation

Link to Full Text

Share

COinS