Pharmaceutical Sciences Faculty Publications
Evaluation of the Antidiarrhoeal Effects of Zizyphus spina-christi Stem Bark in Rats
Document Type
Article
Publication Date
7-2003
Journal Title
Acta Tropica
ISSN
0001-706X
Volume
87
Issue
2
First Page
245
Last Page
250
DOI
http://dx.doi.org/10.1016/s0001-706x(03)00114-1
PubMed ID
12826300
Abstract
The antidiarrhoeal effects of the methanol extract of Zizyphus spina-christi stem bark were evaluated in laboratory rodents. Studies on castor oil induced diarrhoea, intraluminal fluid accumulation, and gastrointestinal transit time were carried out. Results obtained revealed that the extract caused a dose dependent protection of rats against castor oil induced diarrhoea, decreased the intraluminal fluid accumulation and gastrointestinal transit. The intraperitoneal and oral LD50 values were found to be 346±5.6 and 1200±41.2 mg/kg in mice. Preliminary phytochemical screening revealed the presence of glycosides, resins, saponins, and tannins. It is suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiarrhoeal agent.
Keywords
Zizyphus spina-christi, castor oil induced diarrhoea, castor oil induced fluid accumulation, gastrointestinal transit
Recommended Citation
Adzu, B.; Amos, Samson; Amizan, M. B.; and Gamaniel, K., "Evaluation of the Antidiarrhoeal Effects of Zizyphus spina-christi Stem Bark in Rats" (2003). Pharmaceutical Sciences Faculty Publications. 116.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/116