Pharmaceutical Sciences Faculty Publications
Preliminary Studies on Anti-inflammatory and Anti-nociceptive Effects of the Aqueous Extract of Chrysanthellum indicum
Document Type
Article
Publication Date
2002
Journal Title
Acta Pharmaceutica
Volume
52
First Page
213
Last Page
218
Abstract
The aqueous extract of Chrysanthellum indicum (Compositae) was investigated for anti-inflammatory and anti-nociceptive activity. The anti-inflammatory activity was tested against egg-albumin induced oedema, while the analgesic effects were studied using the acetic acid induced writhing in mice. The results revealed that the aqueous extract of C. indicum posseses a significant and dose-dependent anti-inflammatory effect. The extract also inhibited abdominal constriction dose-dependently. The intraperitoneal LD50 in mice was found to be 282.2 mg kg-1. The preliminary phytochemical screening revealed the presence of glycosides, flavonoids, tannins and alkaloids. The results of this study indicate the presence of biologically active substance(s) that may be beneficial in the management of pain and inflammation.
Keywords
Chrysanthellum indicum (compositae), aqueous extract, analgesia, anti-inflammation, flavonoids
Recommended Citation
Amos, Samson; Adamu, M.; Binda, L.; Edmond, I.; Kunle, O. F.; Akah, P.; Wambebe, C.; and Gamaniel, K., "Preliminary Studies on Anti-inflammatory and Anti-nociceptive Effects of the Aqueous Extract of Chrysanthellum indicum" (2002). Pharmaceutical Sciences Faculty Publications. 119.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/119