Pharmaceutical Sciences Faculty Publications
Central Inhibitory Activity of the Aqueous Extract of Crinum giganteum
Document Type
Article
Publication Date
2-2003
Journal Title
Fitoterapia
ISSN
0367-326X
Volume
74
Issue
1-2
First Page
23
Last Page
28
DOI
http://dx.doi.org/10.1016/s0367-326x(02)00287-3
PubMed ID
12628390
Abstract
The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD50 in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity.
Keywords
Crinum giganteum, spontaneous motor activity, pentobarbital sleeping time, exploratory behavior, amphetamine stereotype
Recommended Citation
Amos, Samson; Binda, L.; Akah, P.; Wambebe, C.; and Gamaniel, K., "Central Inhibitory Activity of the Aqueous Extract of Crinum giganteum" (2003). Pharmaceutical Sciences Faculty Publications. 120.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/120