Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats

Authors

Samson Amos, Cedarville UniversityFollow
B. A. Chindo
I. Edmond
P. Akah
C. Wambebe
K. Gamaniel

Document Type

Article

Publication Date

2002

Journal Title

Journal of Herbs, Spices & Medicinal Plants

Volume

9

Issue

1

First Page

47

Last Page

53

DOI

http://dx.doi.org/10.1300/j044v09n01_06

Abstract

The methanolic extract of Ficus platyphylla Del.-Holl. stem bark was investigated for anti-inflammatory and anti-nociceptive activities. The anti-inflammatory activity was tested against egg albumin-induced edema, while the analgesic effects were studied using the acetic acid-induced writhing in mice and formalin test in mice. The results revealed that the aqueous extract of Ficus platyphylla possess significant, dose dependent anti-inflammatory effects. The extract also inhibited pain caused by acetic acid in mice and reduced pain episodes induced by formalin. The intraperitoneal LD₅₀ in mice was 2000 mg/kg.

Keywords

Analgesia, gamji, medicinal plant, oedema

Recommended Citation

Amos, Samson; Chindo, B. A.; Edmond, I.; Akah, P.; Wambebe, C.; and Gamaniel, K., "Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats" (2002). Pharmaceutical Sciences Faculty Publications. 130.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/130