Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats
Journal of Herbs, Spices & Medicinal Plants
The methanolic extract of Ficus platyphylla Del.-Holl. stem bark was investigated for anti-inflammatory and anti-nociceptive activities. The anti-inflammatory activity was tested against egg albumin-induced edema, while the analgesic effects were studied using the acetic acid-induced writhing in mice and formalin test in mice. The results revealed that the aqueous extract of Ficus platyphylla possess significant, dose dependent anti-inflammatory effects. The extract also inhibited pain caused by acetic acid in mice and reduced pain episodes induced by formalin. The intraperitoneal LD50 in mice was 2000 mg/kg.
Analgesia, gamji, medicinal plant, oedema
Amos, Samson; Chindo, B. A.; Edmond, I.; Akah, P.; Wambebe, C.; and Gamaniel, K., "Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats" (2002). Pharmaceutical Sciences Faculty Publications. 130.