Pharmacological Effects of Aqueous Extract of the Chrysanthellum indicum on Gastrointestinal Smooth Muscles

Authors

Samson Amos, Cedarville UniversityFollow
K. Gamaniel
M. Adamu
B. B. Bukar
P. Akah
C. Wambebe

Document Type

Article

Publication Date

2000

Journal Title

Journal of Herbs, Spices & Medicinal Plants

Volume

7

Issue

3

First Page

45

Last Page

53

DOI

http://dx.doi.org/10.1300/j044v07n03_06

Abstract

Aqueous extract of Chrysanthellum indicum DC. (subsp. Afroamericanum B.L. Turner) produced a concentration dependent contraction of the rabbit jejunum, guinea pig ileum, and rat duodenum. The contraction evoked by the extract was not attenuated by mepyramine and pirenzepine, but was abolished by atropine. These actions suggest the presence of biologically active substances in the extract with action mediated through muscarinic receptors. Intraperitoneal LD₅₀ of the extract in mice was 282.2 ± 5.2 mg/kg and preliminary phytochemical screening revealed the presence of glycosides, flavonoids, tannins and alkaloids in the extract.

Keywords

Medicinal plant, muscarinic receptors, traditional medicine

Recommended Citation

Amos, Samson; Gamaniel, K.; Adamu, M.; Bukar, B. B.; Akah, P.; and Wambebe, C., "Pharmacological Effects of Aqueous Extract of the Chrysanthellum indicum on Gastrointestinal Smooth Muscles" (2000). Pharmaceutical Sciences Faculty Publications. 131.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/131