Pharmaceutical Sciences Faculty Publications
Behavioral Effects of the Aqueous Extract of Guiera senegalensis in Mice and Rats
Document Type
Article
Publication Date
2001
Journal Title
Phytomedicine
ISSN
0944-7113
Volume
8
Issue
5
First Page
356
Last Page
361
DOI
http://dx.doi.org/10.1078/0944-7113-00056
PubMed ID
11695878
Abstract
Behavioral effects of the aqueous extract of Guiera senegalensis on the central nervous system of mice and rats were investigated. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behavior, exploratory activity and performance on treadmills (rota-rod) were evaluated. The results revealed that the aqueous extract ofG. senegalensis reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behavior in rats. The extract also decreased exploratory activity in mice and had no observable effects on motor coordination (rota-rod) at the doses tested. The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature.
Keywords
G. senegalensis, gross behavior, pentobarbital sleep, motor coordination, exploratory activity
Recommended Citation
Amos, Samson; Kolawole, E.; Akah, P.; Wambebe, C.; and Gamaniel, K., "Behavioral Effects of the Aqueous Extract of Guiera senegalensis in Mice and Rats" (2001). Pharmaceutical Sciences Faculty Publications. 137.
https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/137
Comments
Journal also known as Phytomedicine: International Journal of Phytotherapy and Phytopharmacology